Sept 21: In a setback for Intarcia Therapeutics, the FDAs Endocrinologic and Metabolic Drugs Advisory Committee voted unanimously that the benefits of its drug-device combination for Type 2 diabetes, ITCA 650, did not outweigh the risks
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In fact, a difference in experimental conditions as well as cell-type specificity of plasticity mechanisms and heterogeneity of recorded subpopulations of interneurons could have contributed to discrepancies between the findings of the above studies, e.g., whether CA1 inhibitory neurons express predominantly LTD (McMahon and Kauer, 1997) or also LTP (Taube and Schwartzkroin, 1987
In cases of CKD, AGEs accumulate and function as uremic toxins
Front Aging Neurosci 11:98 Machado P, Paixo A, Oliveiros B, Martins RA, Cruz J (2025) Effect of home-based exercise prehabilitation on postoperative outcomes in colorectal cancer surgery: a systematic review and meta-analysis