(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)
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Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes-2024
We obtained the data for this review from PubMed, Scopus, Web of Science, and ClinicalTrials.gov, using the following keywords: obesity, type 2 diabetes, new drug treatment, recent developments, clinical studies, G-protein-coupled receptor, glucagon-like peptide-1 receptor agonists, glucose-dependent insulinotropic polypeptide receptor agonist, glucagon receptor agonist, dual agonist, and triple agonist. 2
