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J Biol Chem 283:1424814256 MacDonald MJ, Smith AD 3rd, Hasan NM, Sabat G, Fahien LA (2007) Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell

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GDH hyperactivity leads to increased consumption of glutamate, resulting in reduced synthesis of GABA and disrupting the balance in neurotransmission [19]