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The strategic asset in the Caremark acquisition was not a patent portfolio in the conventional pharma sense, but rather a proprietary formulary management system, specialty pharmacy infrastructure (including Specialty Pharmacy Networks and the Accordant chronic disease management programs), and a mail-order fulfillment network that generated high-margin prescription volume outside retail pharmacy economics

In humans, large proportions of orally administered d-allulose are absorbed and subsequently excreted via the urine without being metabolized 14

The 0.4 mg difference reflects the dose found optimal for weight loss in the STEP trials vs the dose found optimal for glycemic control in the SUSTAIN trials