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Hypertensive Urgencies and Emergencies The classification of hypertensive urgencies and emergencies is determined by the presence or absence of acute target organ damage, not by BP, and determines the appropriate treatment approach

Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

A landmark study published in Science Translational Medicine in 2015 provided molecular evidence for this association

Wash your hands thoroughly and wear disposable gloves